Product ID:THROMBIN FROM BOVINE PLASMA, T4265
MSDS Date:01/01/1999
FSC:6505
NIIN:00N093152
Status Code:A
MSDS Number: CJXKD

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

THROMBIN

CAS: 9002-04-4

RTECS: XO8950000

Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE FATAL IF ENTERS
BLOODSTREAM. MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN
ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION.
MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRA NES AND UPPER
RESPIRATORY TRACT. PROLONGED OR REPEATED EXPOSURE MAY CAUSE
ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. INVOLVED IN
CLOTTING. TARGET ORGAN(S): VASCULAR SYSTEM. TO THE BEST OF MF R
KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPERTIES
HAVE NOT BEEN THOROUGHLY INVESTIGATED.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES OR SKIN WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING
CONTAMINATED CLOTHING AND SHOES. ASSURE ADEQUATE FLUSHING OF THE
EYES BY SEPARAT ING THE EYELIDS WITH FINGERS. IF INHALED, REMOVE TO
FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF
BREATHING IS DIFFICULT, GIVE OXYGEN. IF SWALLOWED, WASH OUT MOUTH
WITH WATER PROVIDED PE RSON IS CONSCIOUS. CALL PHYSICIAN. WASH
CONTAMINATED CLOTHING BEFORE REUSE.

Extinguishing Media:NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE
TO SURROUNDING FIRE CONDITONS.
Fire Fighting Procedures:WEAR NIOSH APRPOVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:WEAR NIOSH APPRVD RESPIRATOR, CHEMICAL SAFETY
GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED MATERIAL
SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND REMOVED.
VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS
COMPLETE.

Handling and Storage Precautions:AVOID INHALATION. DO NOT GET IN EYES,
ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. DO NOT
USE IF SKIN IS CUT OR SCRATCHED. KEEP TIGHTLY CLOSED. STORE IN A
COOL DRY PLACE.

Respiratory Protection:WEAR APPROPRIATE NIOSH-APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

Solubility in Water:SOLUBLE
Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:NATURE OF DECOMPOSITION PRODUCTS NOT
KNOWN.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS #: XO8950000. THROMBIN. TOX DATA:
IPR-RAT LD50:>40 ML/KG OYYAA2 28,329,1984. SCU-RAT LD50:>40 ML/KG
OYYAA2 28,329,1984. SKN-MUS LD50:>3 GM/KG YACHDS 1,272,1973.
IPR-MUS LD50:>50 M./KG OYYAA2 28, 329,1984. SCU-MUS LD50:>50 ML/KG
066AA2 28,329,1984. INV-MUS LD50:7771 UG/KG YACHDS 16,669,1988.
TARGET ORGAN DATA: BEHAVIORAL (ALTERED SLEEP TIME). LUNGS, THORAX
OR RESPIRATION (OTHER CHANGES). KIDNE Y, URETER, BLADDER (OTHER
CHANGES). ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL
SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN
RTECS FOR COMPLETE INFORMATION.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:REVIEWS, STANDARDS, AND REGULATIONS.
OEL=MAK. NOES 1983: HAZD X3641; NIS 3; TNF 339, NOS 7; TNE 7383;
TFE 5915. EPA TSCA SECTION 8(B) CHEMICAL INVENTORY.